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Talking Studies #002: GLP-1 Receptor Agonists, Lean Mass, and Exercise

Can Exercise Mitigate Lean Body Mass Losses While Taking Liraglutide During a Weight-Loss Maintenance Phase

In this episode of the Talking Studies Series, I cover a fairly hot topic: GLP-1 receptor agonists (GLP-1RAs), the popular weight-loss drugs.

Specifically, I cover a study that tested exercise, liraglutide (a GLP-RA), and liraglutide plus exercise as interventions for maintaining weight-loss. And, I zero in on how both the original liraglutide-free weight-loss period and the different interventions during the maintenance phase impacted lean mass—a proxy for muscle mass.


Links from the video:

Main Study Discussed (https://www.nejm.org/doi/10.1056/NEJMoa2028198)

“Preserving Healthy Muscle during Weight Loss”

A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity”

“Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis”

“GLP-1 receptor agonists: an updated review of head-to-head studies”


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Linking the Why's, How's, and What's of Health and Fitness Through Expert Voices.