In this episode of the Talking Studies Series, I cover a fairly hot topic: GLP-1 receptor agonists (GLP-1RAs), the popular weight-loss drugs.
Specifically, I cover a study that tested exercise, liraglutide (a GLP-RA), and liraglutide plus exercise as interventions for maintaining weight-loss. And, I zero in on how both the original liraglutide-free weight-loss period and the different interventions during the maintenance phase impacted lean mass—a proxy for muscle mass.
Links from the video:
Main Study Discussed (https://www.nejm.org/doi/10.1056/NEJMoa2028198)
“Preserving Healthy Muscle during Weight Loss”
“A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity”
“Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis”
“GLP-1 receptor agonists: an updated review of head-to-head studies”
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